FINASTERIDE INFLUENCE ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
نویسندگان
چکیده
منابع مشابه
Influence of functional MDR1 gene polymorphisms on P-glycoprotein activity in CD34+ hematopoietic stem cells.
BACKGROUND AND OBJECTIVES Expression of the multidrug resistance P-glycoprotein, a transmembrane drug transporter, is influenced by recently described polymorphisms of the human MDR1 gene. Hematopoietic cells, such as lymphocytes, and hematopoietic stem cells, express P-glycoprotein, but the effect of MDR1 gene polymorphisms on P-glycoprotein activity in stem cells is unknown. We investigated w...
متن کاملEffect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers
The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...
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Compounds known to modulate P-glycoprotein (P-gp) activity were evaluated in cell monolayers expressing P-gp for their effects on the secretory transport of P-gp substrates paclitaxel, vinblastine, and digoxin. Paclitaxel has been proposed to selectively interact with a binding site on P-gp that is distinct from the vinblastine and digoxin-binding site. Using Madin-Darby canine kidney (MDCK)-mu...
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BACKGROUND Overexpression of ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) or breast cancer resistance protein (BCRP) accounts for majority of cases of multidrug resistance (MDR) of cancer cells. MATERIALS AND METHODS In the present work, the interactions of seven commercially available phenothiazine derivatives, known ...
متن کاملeffect of honey on cyp3a4 enzyme and p-glycoprotein activity in healthy human volunteers
the activity of cytochrome p450 isozyme 3a4 (cyp3a4) enzyme and p-glycoprotein (p-gp) is modulated by grapefruit juice and herbal drugs. cyp3a4 is the major phase i drug metabolizing enzyme and p-gp is an atp-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. honey is commonly consumed as a dietary supplement. however, its influence on human cyp3a4...
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ژورنال
عنوان ژورنال: I.P.Pavlov Russian Medical Biological Herald
سال: 2012
ISSN: 2500-2546,0204-3475
DOI: 10.17816/pavlovj2012446-50